Aerosols are solid or liquid particles suspension in air, which are naturally present in the form of dust, smoke, etc. From the toxicologic point of view, these particles have the potential of being biologically active in susceptible indiv
iduals. Therefore, it is vital to understand how these deposited particles are being cleared out of the respiratory system. Muco-ciliary clearance, the transport of foreign particles deposited on the lung airway surfaces by a blanket of mucus, is recognized as the principle as well as the fastest clearance mechanism in the trachea-bronchial region where the an array
of cilia beat rapidly and propel the mucus, together with entrapped particulate materials (that might damage the lungs), from the airways towards the larynx. This research project aims to develop an advanced numerical model which can simulate the muco-ciliary clearance in a more realistic manner by considering a flexible structure for cilia beating on the lung epithelial cells and transporting airway surface liquid in normal functioning and disease.